This session focuses on the way forward with syndemic approaches to eliminate HIV, viral hepatitis, and related epidemics in a political environment characterized by significantly diminished federal investment in infectious disease prevention and treatment, and in overdose crisis response.  The goal is to explore the impact of Reductions in Force at HHS, reduced funding to academic institutions, and other funding and workforce changes on our capacity to end HIV, viral hepatitis, and overdose mortality, with a particular focus on how these changes will impact adults over the age of 50; as well as exploring how syndemic approaches may provide opportunities to engage the expertise and resources of the remaining public health workforce to respond to these ongoing public health crises through innovative collaboration.