This study examines media bias and stigma in Florida news coverage of HIV-related arrests from 2010 to 2020. A systematic content analysis of 129 news articles revealed disproportionate racial and gender portrayals, with Black men overrepresented as perpetrators despite data showing White women constitute the majority of those arrested. Findings indicate widespread use of stigmatizing language and sensationalized reporting, which amplify public misconceptions about HIV transmission and criminalization. These narratives contribute to public fear, reinforce systemic biases, and undermine public health efforts. The study offers recommendations for journalists and policymakers to promote accurate, non-stigmatizing HIV reporting.