Queen City Harm Reduction (QCHR) is the only organization expressly centered around harm reduction principles and syringe access in Mecklenburg County, North Carolina, where the city of Charlotte is based, and seeks to minimize the harms associated with substance use and other intersecting conditions such as sex work, justice involvement, and homelessness. QCHR proactively educates peers and the community on drug user health promoting prevention of infectious disease, overdose, and compassionate care.