Holy Cross Health in Fort Lauderdale, Florida, is advancing health equity through a comprehensive, community-based approach to HIV prevention and care, STI and Hepatitis C screening, and LGBTQ+ health. Broward County remains one of the nation’s HIV epicenters, with 579 new diagnoses in 2022, far exceeding the national average. Despite this, 96.2 percent of people living with HIV in the county know their status, and 80.8 percent are linked to care within one month. Holy Cross Health’s initiatives, such as community outreach, HIV self-testing, and culturally competent education, are designed to meet the needs of LGBTQ+ individuals who are disproportionately affected by these conditions. The program is led by community advocates and LGBTQ+ healthcare professionals who step beyond traditional clinical roles to engage directly with the community. This session will explore the program’s design, implementation, and measurable impact, offering a replicable model for other health systems.