Culturally informed care is vital for linking diverse women to treatment, prevention, and testing services for HIV, syphilis, and hepatitis C (HCV). Untreated STIs pose serious health risks for women which can lead to long-term complications. Despite ongoing national calls to expand prevention and treatment, syphilis rates have increased 6.8% amongst women ages 15-44 from 2022-2023. Congenital syphilis is currently at its highest since 1992. Due to persistent disparities in testing and diagnosis, women are more likely to be diagnosed with HIV at older ages, particularly Black women. Historically, women have been underrepresented in HIV testing, prevention and treatment initiatives. Women have low rates of biological prevention method uptake, such as PrEP, despite increased diagnosis rates. Although women account for 18% of new HIV diagnoses in the U.S, women make up only 8% of PrEP users. Opt-out Emergency Department (ED) testing programs are instrumental for increasing testing rates and improving prevention access for women, particularly in communities experiencing disparities. Patient navigation teams play an integral role in bridging the gap between ED testing and follow-up services, including treatment and prevention beyond the ED. Referring patients to community gynecological providers has proved an effective strategy for connecting women to preventative care following ED-based screening.