With advancements in HIV treatment, individuals living with HIV are now living longer, By 2030, 70% of people living with HIV (PLWH) will be ages 50 and older. But, as PLWH age they face unique challenges, particularly with cognitive health. One major concern is HIV-Associated Neurocognitive Disorder (HAND), a form of cognitive decline more common among PLWH. This presentation will provide a brief overview of HIV care; the signs and risk factors for HAND; similarities and differences between HAND and Alzheimer’s disease; and why accurately diagnosing cognitive change in PLWH is so important.