This interactive presentation explores the intersection of sexual pleasure, HIV prevention, and liberation for communities of color. The Science of Sexuality and Pleasure, it reframes PrEP and PEP not just as biomedical tools, but as instruments of sexual agency, protection, and empowerment. Drawing on the imagery of chains, whips, handcuffs, and doxycycline, we assert that protection and pleasure are not mutually exclusive, but deeply intertwined. Through storytelling, case-based dialogue, and visual metaphors, we invite attendees to challenge conventional narratives that separate safety from desire. This session is rooted in affirming sex-positive, stigma-free frameworks that normalize both protection and play, while recognizing that the full spectrum of sexual expression, particularly for people of color, has been historically policed and pathologized. Our aim is to reimagine prevention as liberation, pleasure as resistance, and protection as power.