This session showcases how nurses are transforming HIV prevention in one of the nation’s highest-incidence regions. This innovative, nurse-led model expands access to pre-exposure prophylaxis (PrEP) through standing orders, telehealth, and mobile outreach, allowing same-day initiation of care. By empowering nurses to manage 96% of PrEP cases and tailoring services to uninsured, LGBTQ+, migrant, and communities of color, PrEPared RN has increased uptake by 86% and now delivers 67% of all PrEP care at CAN Community Health in South Florida. The session highlights how this scalable model integrates cultural responsiveness, community partnership, and clinical innovation to advance health equity and accelerate progress toward ending the HIV epidemic.