This presentation will explore critical considerations in the management of HIV in the context of pregnancy, focusing on evidence-based practices and clinical guidelines. Divided into three clinically relevant scenarios, the session will address: (1) treatment and monitoring of HIV in pregnant individuals, (2) postnatal management of infants with in utero exposure to HIV, and (3) considerations for HIV-positive parents who plan to breastfeed. Each topic will be anchored by a clinical case, offering participants an opportunity to apply current guidelines. Emphasis will be placed on reducing risk of perinatal HIV transmission, optimizing maternal and infant outcomes, and navigating ethical and cultural factors in decision making. Attendees will leave with practical clinical pearls and an updated understanding of best practices in HIV care during pregnancy and the postpartum period.