A translational research project implemented at a Sacramento County sexual health center to reduce barriers to Hepatitis C virus (HCV) treatment. To address elevated prevalence of Hepatitis C in the area, Sacramento County Public Health’s Sexual Health Clinic (SHC) opted to participate in a research project to develop and implement organizational supports and workflows to improve rates of HCV treatment for patients served in this setting. Over a three-month period the SHC increased HCV treatment rates from zero to 44% of HCV+ patients seen in clinic. This included priority patients living with HCV, such as people living with HIV, people engaged in active substance abuse, and people experiencing housing instability. Challenges to implementation were managed using a continuous quality improvement approach and multidisciplinary collaboration.