As interest in long‑acting injectable (LAI) HIV treatment and PrEP continues to grow, many healthcare sites face real‑world challenges translating enthusiasm into sustainable programs. This peer‑to‑peer panel focuses on the practical “how” of LAI implementation, featuring external experts with hands‑on experience navigating operational workflows, site‑level decision‑making, and reimbursement considerations across medical benefit (buy‑and‑bill) and pharmacy benefit models. The discussion will also include an internal ViiV representative, the Head of Global Implementation Sciences, who will highlight the critical role nurses, pharmacists, and other advanced practice providers play as part of the interdisciplinary care team in successfully designing, operationalizing, and sustaining LAI programs. Through real‑world examples and lessons learned, attendees will gain insight into how LAI program design varies by site infrastructure, payer mix, and patient population—and how to identify implementation pathways that best fit their own settings.