To address the intersecting epidemics of HIV, Hepatitis C (HCV), and syphilis in Miami-Dade County, Baptist Health South Florida (BHSF) expanded its innovative Electronic Health Record (EHR) syndemic screening model across multiple emergency departments in 2024. Building on the success of Homestead Hospital (HH) and West Kendall Baptist Hospital’s (WKBH) routine HIV/HCV screening program, Baptist Main Hospital (BMH) and South Miami Hospital (SMH) implemented scalable workflows and smart syphilis screening algorithms into their EHR. This expansion was supported by strategic public-private partnerships with hospital leadership and the Florida Department of Health in Miami-Dade County (DOH-Miami-Dade) which provided a dedicated Disease Intervention Specialists (DIS) to ensure timely linkage to care and prevention services.