Queen City Harm Reduction (QCHR) is the only organization expressly centered around harm reduction principles and syringe access in Mecklenburg County, North Carolina, where the city of Charlotte is based, and seeks to minimize the harms associated with substance use and other intersecting conditions such as sex work, justice involvement, and homelessness. QCHR proactively educates peers and the community on drug user health promoting prevention of infectious disease, overdose, and compassionate care. Through an extensive testing and linkage program, it has become clear that when full wrap-around services are offered within a trusted SSP, there will be fewer barriers for people who use drugs (PWUD), people engaging in sex work, and other marginalized populations to access care. Education is also more accessible for these populations when it is provided in a setting where they have trust and rapport with the outreach workers providing it, as well as where they have access to supplies needed to engage in prevention practices.