This plenary session will spark a greater understanding of syndemics by exploring how health conditions intertwined with social determinants create significant health challenges in addition to opportunities to advance health equity positions—particularly among LGBTQ+ communities. The discussion will fuel specialized, patient-centric policies and programs, offering actionable ideas and ideals to address these unique challenges. The session will underscore the importance of inclusive representation in shaping health policies by employing a syndemic framework. This approach fosters a comprehensive approach to health equity and creates supportive environments for all community members, especially those grappling with overlapping social and health challenges in current times.