This presentation will discuss the opportunities for implementing linkage to comprehensive services by assessing populations who are seen in the ED testing for STIs, including syphilis and HIV. We will explore the operations of identifying eligible patients, including our collaborations with the public health department, our Infectious Disease Clinic, and our Title V Clinic. We will highlight what is going well and discuss areas of improvement.
This presentation will also review the successes and challenges of launching a rapid PrEP program in an ED setting.

As part of the Hillsborough Health Equity Plan, a formative research initiative was conducted to increase the uptake of pre-exposure prophylaxis (PrEP) among Black and Latinx men who have sex with men (MSM) aged 25–34 in Hillsborough County, Florida. The study explored patient and provider experiences within on-demand care settings, such as urgent care clinics and emergency departments (EDs), where opportunities for PrEP intervention are often missed.

The North Jersey Community Research Initiative (NJCRI) conducted a retrospective chart review to evaluate real-world utilization of oral and long-acting injectable PrEP (LA-Cabotegravir) among individuals accessing services between 2024 and 2025. NJCRI serves a predominantly Black and Brown, urban population in Newark, NJ, many of whom face housing instability, food insecurity, and limited access to affirming healthcare.

The U.S. has approved long-acting injectable PrEP options such as cabotegravir (Apretude) and lenacapavir (Yzugo), yet major challenges remain around equitable access, demand generation, and health-system readiness. This project explores what the United States can learn from low- and middle-income countries (LMICs) that successfully expanded injectable contraceptives, an intervention with striking parallels to injectable PrEP.

Since 2018, Texas has faced a steep rise in syphilis cases particularly among marginalized groups such as Hispanic and non-Hispanic Black individuals. These findings are parallel to HIV trends in Texas. This model merges surveillance with proactive prevention and clinical coordination, targeting individuals at heightened HIV risk. Ongoing data collection on patient demographics, barriers, and facilitators will optimize implementation and elevate prevention outcomes in underserved communities.